coisas da química #14 / a maria gosta #18

hoje (oficialmente) o fred, o marco e eu tornámo-nos angewandte friends forever :) <3

A Versatile and Stereoselective Synthesis of Functionalized Cyclobutenes
by Frédéric Frébault, Marco Luparia, Maria Teresa Oliveira, Richard Goddard, Nuno Maulide

Square flat: A new atom-economical method for the synthesis of functionalized cyclobutenes has been developed. This versatile sequence hinges upon a unique combination of an elegant photochemical isomerization and a palladium-catalyzed alkylation, and converts the readily available, "flat" aromatic 2-pyrone into a variety of functionalized products with exquisite stereoselectivity.

online today!

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